Elevated Snail expression in human gingival fibroblasts by cyclosporine A as the possible pathogenesis for gingival overgrowth
نویسندگان
چکیده
منابع مشابه
Cyclosporine-A Induced Gingival Overgrowth
Background. The link between the gingival overgrowth and cyclosporine pharmacokinetical variables, especially cyclosporine doses which appear to act as stimulator of the gingival proliferative changes, presents a field of interest of large number of researches. The existence of undefined association and/or interaction between the cyclosporine and periodontal variables, could be responsible for ...
متن کاملUpdate on gingival overgrowth by cyclosporine A in renal transplants.
Severe gingival overgrowth is one of the most frequent side effects in renal transplant patients associated with assumption of cyclosporine A. Several associations with age, sex, dosage, duration of therapy or interval since transplantation have been hypothesized. The introduction of alternative immunosuppressant drugs have been suggested to permit better long-term transplant outcomes and a dec...
متن کاملCytokine secretion in cultured human gingival fibroblasts in response to LPS or gingival overgrowth-inducing drugs
Human normal, periodontitis and overgrown gingival fibroblasts were assayed concerning proinflammatory cytokines secreting ability. Stimulating effect of gingival overgrowth-inducing drugs such as phenytoin, nifedipine or cyclosporine A and LPS on the secretion ability of each fibroblast specimen was also estimated. The supernatant of cultured medium was assayed cytokines by ELISA techniques. I...
متن کاملThe Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth
Gingival overgrowth is a side effect of certain medications. The most fibrotic drug-induced lesions develop in response to therapy with phenytoin, the least fibrotic lesions are caused by cyclosporin A, and the intermediate fibrosis occurs in nifedipine-induced gingival overgrowth. Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because o...
متن کاملTreatment of cyclosporine-induced gingival overgrowth with azithromycin-containing toothpaste.
OBJECTIVES Gingival overgrowth is a complication of cyclosporine therapy following organ transplantation. Oral azithromycin is frequently used to treat this complication. This study examined the efficacy of local azithromycin, in the form of toothpaste, against cyclosporine-induced gingival overgrowth. MATERIALS AND METHODS Twenty stable renal transplanted patients (10 men and 10 women) with ...
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ژورنال
عنوان ژورنال: Journal of the Formosan Medical Association
سال: 2015
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2015.11.003